After being sent for an early bath with the scores locked at 1-1, he was forced to watch on as Arsenal conceded twice more to slip to a 4-3 aggregate defeat.
Van Persie felt the match officials cost the Gunners a place in the last eight, with his sending off turning the tide at a crucial stage of the game.
"It had a big influence," he told Sky Sports.
"I think it was a total joke. How can I hear his whistle with 95,000 people jumping up? How can I hear it? Please explain that?
"I can't understand the view from the ref. One second from his whistle to my shot is a joke. He has been bad all evening. He was against us. I don't know why he was here tonight, it's a joke.
"We feel betrayed, almost. We tried really hard. When it was 1-1 it was all to play for. But, in my opinion, the ref killed the game."







